Important Safety Information

<span style="-webkit-text-stroke-width:0px;background-color:rgb(255, 255, 255);caret-color:rgb(102, 102, 102);color:rgb(102, 102, 102);display:inline !important;float:none;font-family:Verdana, Geneva, sans-serif;font-size:10px;font-style:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;orphans:auto;text-align:left;text-decoration:none;text-indent:0px;text-transform:none;white-space:normal;widows:auto;word-spacing:0px;">Lorem ipsum dolor sit amet, consectetuer adipiscing elit. Aenean commodo ligula eget dolor. Aenean massa. Cum sociis natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Donec quam felis, ultricies nec, pellentesque eu, pretium quis, sem. Nulla consequat massa quis enim. Donec pede justo, fringilla vel, aliquet nec, vulputate eget, arcu. In enim justo, rhoncus ut, imperdiet a, venenatis vitae, justo. Nullam dictum felis eu pede mollis pretium. Integer tincidunt. Cras dapibus. Vivamus elementum semper nisi. Aenean vulputate eleifend tellus. Aenean leo ligula, porttitor eu, consequat vitae, eleifend ac, enim. Aliquam lorem ante, dapibus in, viverra quis, feugiat a, tellus. Phasellus viverra nulla ut metus varius laoreet.

Indication Information

<span class="primary_01-c" style="-webkit-text-stroke-width:0px;background-color:rgba(162, 166, 174, 0.08);color:rgb(23, 43, 77);display:inline !important;float:none;font-family:-apple-system, &quot;system-ui&quot;, &quot;Segoe UI&quot;, Roboto, Oxygen, Ubuntu, &quot;Fira Sans&quot;, &quot;Droid Sans&quot;, &quot;Helvetica Neue&quot;, sans-serif;font-size:14px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:-0.07px;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;white-space:pre-wrap;widows:2;word-spacing:0px;">ISI Title Important Safety Information&nbsp; PI modal-Freeform <a href="https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal">https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal</a> <a href="https://www.gmail.pdf/#pi-modal">https://www.gmail.pdf#pi-modal</a> <a href="https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal">https://www.novartis.com/us-en/sites/n</a>

Before starting COSENTYX, tell your doctor if you:<ul class="ul1"><li class="li1">are being treated for an infection</li><li class="li1">have an infection that does not go away or that keeps coming back</li><li class="li1">have TB or have been in close contact with someone with TB</li><li class="li1">think you have an infection or have symptoms of an infection, such as: fevers, sweats, or chills; muscle aches; cough; shortness of breath; blood in your phlegm; weight loss; warm, red, or painful skin or sores on your body; diarhea or stomach pain; burning when you urinate or urinate more often than normal</li></ul>After starting COSENTYX, call your doctor right away if you have any signs of infectionPI modal-Freeform<a href="https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal">https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal</a><a href="https://www.gmail.pdf/#pi-modal">https://www.gmail.pdf#pi-modal</a><a href="https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal">https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal</a><a href="https://www.gmail.com/#pi-modal">https://www.gmail.com#pi-modal-External link</a><a href="https://www.google.com/#pi-modal">google.com-whitelist</a><a href="https://www.cosentyxhcp.com.pdf/#pi-modal">Allow list-cosentyxhcp</a><a href="https://www.google.com">https://www.google.com</a>

<span style="-webkit-text-stroke-width:0px;background-color:rgb(255, 255, 255);color:rgb(35, 36, 41);display:inline !important;float:none;font-family:&quot;system-ui&quot;, -apple-system, &quot;Segoe UI&quot;, Roboto, Oxygen-Sans, Ubuntu, Cantarell, &quot;Helvetica Neue&quot;, sans-serif;font-size:14.224px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;letter-spacing:normal;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;">Indication body fullPI modal-Freeform<a href="https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal">https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal</a><a href="https://www.gmail.pdf/#pi-modal">https://www.gmail.pdf#pi-modal</a><a href="https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal">https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal</a><a href="https://www.gmail.com/#pi-modal">https://www.gmail.com#pi-modal-External link</a><a href="https://www.google.com/#pi-modal">google.com-whitelist</a><a href="https://www.cosentyxhcp.com.pdf/#pi-modal">Allow list-cosentyxhcp</a>

<span style="-webkit-text-stroke-width:0px;background-color:rgb(255, 255, 255);color:rgb(35, 36, 41);display:inline !important;float:none;font-family:&quot;system-ui&quot;, -apple-system, &quot;Segoe UI&quot;, Roboto, Oxygen-Sans, Ubuntu, Cantarell, &quot;Helvetica Neue&quot;, sans-serif;font-size:14.224px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;letter-spacing:normal;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;">Indication Title PI modal-Freeform <a href="https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal">https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal</a> <a href="https://www.gmail.pdf/#pi-modal">https://www.gmail.pdf#pi-modal</a> <a href="https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal">https://www.novartis.com/us-en/sites/novartis_us/files/cosen</a>

COSENTYX is a medicine that affects your immune system. COSENTYX may increase your risk of having serious side effects such as:InfectionsCOSENTYX may lower the ability of your immune system to fight infections and may increase your risk of infections, sometimes serious.<ul class="ul1"><li class="li1">Your doctor should check you for tuberculosis (TB) before starting treatment with COSENTYX.</li><li class="li1">If your doctor feels that you are at risk for TB, you may be treated with medicine for TB before you begin treatment with COSENTYX and during treatment with COSENTYX.</li></ul>• •&nbsp; &nbsp;Your doctor should watch you closely for signs and symptoms of TB during treatment with COSENTYX.&nbsp;Do not take COSENTYX if you have an active TB infection.PI modal-Freeform<a href="https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal">https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal</a><a href="https://www.gmail.pdf/#pi-modal">https://www.gmail.pdf#pi-modal</a><a href="https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal">https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal</a><a href="https://www.gmail.com/#pi-modal">https://www.gmail.com#pi-modal-External link</a><a href="https://www.google.com/#pi-modal">google.com-whitelist</a><a href="https://www.cosentyxhcp.com.pdf/#pi-modal">Allow list-cosentyxhcp</a><a href="https://www.google.com">https://www.google.com</a>

<span style="-webkit-text-stroke-width:0px;background-color:rgb(255, 255, 255);color:rgb(35, 36, 41);display:inline !important;float:none;font-family:&quot;system-ui&quot;, -apple-system, &quot;Segoe UI&quot;, Roboto, Oxygen-Sans, Ubuntu, Cantarell, &quot;Helvetica Neue&quot;, sans-serif;font-size:14.224px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;letter-spacing:normal;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;">Indication body shortPI modal-Freeform<a href="https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal">https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal</a><a href="https://www.gmail.pdf/#pi-modal">https://www.gmail.pdf#pi-modal</a><a href="https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal">https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal</a><a href="https://www.gmail.com/#pi-modal">https://www.gmail.com#pi-modal-External link</a><a href="https://www.google.com/#pi-modal">google.com-whitelist</a><a href="https://www.cosentyxhcp.com.pdf/#pi-modal">Allow list-cosentyxhcp</a>

Prescribing Information (PI)

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