Important Safety Information 2

Indication Information

<span class="neutral_70-c" style="-webkit-text-stroke-width:0px;background-color:rgba(162, 166, 174, 0.08);color:rgb(23, 43, 77);display:inline !important;float:none;font-family:-apple-system, &quot;system-ui&quot;, &quot;Segoe UI&quot;, Roboto, Oxygen, Ubuntu, &quot;Fira Sans&quot;, &quot;Droid Sans&quot;, &quot;Helvetica Neue&quot;, sans-serif;font-size:14px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:-0.07px;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;white-space:pre-wrap;widows:2;word-spacing:0px;">ISI Title Important Safety Information&nbsp; PI modal-Freeform <a href="https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal">https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal</a> <a href="https://www.gmail.pdf/#pi-modal">https://www.gmail.pdf#pi-modal</a> <a href="https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal">https://www.novartis.com/us-en/sites/n</a>

Before starting COSENTYX, tell your doctor if you:<ul class="ul1 core_neutral_80-c"><li class="li1">are being treated for an infection</li><li class="li1">have an infection that does not go away or that keeps coming back</li><li class="li1">have TB or have been in close contact with someone with TB</li><li class="li1">think you have an infection or have symptoms of an infection, such as: fevers, sweats, or chills; muscle aches; cough; shortness of breath; blood in your phlegm; weight loss; warm, red, or painful skin or sores on your body; diarhea or stomach pain; burning when you urinate or urinate more often than normal</li></ul>After starting COSENTYX, call your doctor right away if you have any signs of infectionPI modal-Freeform<a href="https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal">https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal</a><a href="https://www.gmail.pdf/#pi-modal">https://www.gmail.pdf#pi-modal</a><a href="https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal">https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal</a><a href="https://www.gmail.com/#pi-modal">https://www.gmail.com#pi-modal-External link</a><a href="https://www.google.com/#pi-modal">google.com-whitelist</a><a href="https://www.cosentyxhcp.com.pdf/#pi-modal">Allow list-cosentyxhcp</a><a href="https://www.google.com">https://www.google.com</a>

<span style="-webkit-text-stroke-width:0px;background-color:rgb(255, 255, 255);color:rgb(35, 36, 41);display:inline !important;float:none;font-family:&quot;system-ui&quot;, -apple-system, &quot;Segoe UI&quot;, Roboto, Oxygen-Sans, Ubuntu, Cantarell, &quot;Helvetica Neue&quot;, sans-serif;font-size:14.224px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;letter-spacing:normal;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;">Indication body fullPI modal-Freeform<a href="https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal">https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal</a><a href="https://www.gmail.pdf/#pi-modal">https://www.gmail.pdf#pi-modal</a><a href="https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal">https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal</a><a href="https://www.gmail.com/#pi-modal">https://www.gmail.com#pi-modal-External link</a><a href="https://www.google.com/#pi-modal">google.com-whitelist</a><a href="https://www.cosentyxhcp.com.pdf/#pi-modal">Allow list-cosentyxhcp</a>

<span style="-webkit-text-stroke-width:0px;background-color:rgb(255, 255, 255);color:rgb(35, 36, 41);display:inline !important;float:none;font-family:&quot;system-ui&quot;, -apple-system, &quot;Segoe UI&quot;, Roboto, Oxygen-Sans, Ubuntu, Cantarell, &quot;Helvetica Neue&quot;, sans-serif;font-size:14.224px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;letter-spacing:normal;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;">Indication Title PI modal-Freeform <a href="https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal">https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal</a> <a href="https://www.gmail.pdf/#pi-modal">https://www.gmail.pdf#pi-modal</a> <a href="https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal">https://www.novartis.com/us-en/sites/novartis_us/files/cosen</a>

COSENTYX is a medicine that affects your immune system. COSENTYX may increase your risk of having serious side effects such as:InfectionsCOSENTYX may lower the ability of your immune system to fight infections and may increase your risk of infections, sometimes serious.<ul class="ul1"><li class="li1">Your doctor should check you for tuberculosis (TB) before starting treatment with COSENTYX.</li><li class="li1">If your doctor feels that you are at risk for TB, you may be treated with medicine for TB before you begin treatment with COSENTYX and during treatment with COSENTYX.</li></ul>• • &nbsp; Your doctor should watch you closely for signs and symptoms of TB during treatment with COSENTYX.&nbsp;Do not take COSENTYX if you have an active TB infection.PI modal-Freeform<a href="https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal">https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal</a><a href="https://www.gmail.pdf/#pi-modal">https://www.gmail.pdf#pi-modal</a><a href="https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal">https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal</a><a href="https://www.gmail.com/#pi-modal">https://www.gmail.com#pi-modal-External link</a><a href="https://www.google.com/#pi-modal">google.com-whitelist</a><a href="https://www.cosentyxhcp.com.pdf/#pi-modal">Allow list-cosentyxhcp</a><a href="https://www.google.com">https://www.google.com</a>

<span style="-webkit-text-stroke-width:0px;background-color:rgb(255, 255, 255);color:rgb(35, 36, 41);display:inline !important;float:none;font-family:&quot;system-ui&quot;, -apple-system, &quot;Segoe UI&quot;, Roboto, Oxygen-Sans, Ubuntu, Cantarell, &quot;Helvetica Neue&quot;, sans-serif;font-size:14.224px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;letter-spacing:normal;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;">Indication body shortPI modal-Freeform<a href="https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal">https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal</a><a href="https://www.gmail.pdf/#pi-modal">https://www.gmail.pdf#pi-modal</a><a href="https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal">https://www.novartis.com/us-en/sites/novartis_us/files/cosentyx.pdf#pi-modal</a><a href="https://www.gmail.com/#pi-modal">https://www.gmail.com#pi-modal-External link</a><a href="https://www.google.com/#pi-modal">google.com-whitelist</a><a href="https://www.cosentyxhcp.com.pdf/#pi-modal">Allow list-cosentyxhcp</a>

Prescribing Information (PI)

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